Comparative Analysis of Polysaccharide and Cell Wall Structure in <i>Aspergillus nidulans</i> and <i>Aspergillus fumigatus</i> by Solid-State NMR.

ABSTRACT: Invasive aspergillosis poses a significant threat to immunocompromised patients, leading to high mortality rates associated with these infections. Targeting the biosynthesis of cell wall carbohydrates is a promising strategy for antifungal drug development and will be advanced by a molecular-level understanding of the native structures of polysaccharides within their cellular context. Solid-state NMR spectroscopy has recently provided detailed insights into the cell wall organization of Aspergillus fumigatus, but genetic and biochemical evidence highlights species-specific differences among Aspergillus species. In this study, we employed a combination of ¹³C, ¹⁵N, and ¹H-detection solid-state NMR, supplemented by Dynamic Nuclear Polarization (

SUBMITTER: Gautam I 

PROVIDER: S-EPMC11343165 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature