Emerging <i>Clostridioides difficile</i> ribotypes have divergent metabolic phenotypes.

ABSTRACT: Clostridioides difficile is a gram-positive spore-forming pathogen that commonly causes diarrheal infections in the developed world. Although C. difficile is a genetically diverse species, certain ribotypes are overrepresented in human infections. It is unknown if metabolic adaptations are essential for the emergence of these epidemic ribotypes. Here, we tested carbon substrate utilization by 88 C. difficile isolates and looked for differences in growth between 22 ribotypes. By profiling clinical isolates, we assert that C. difficile is a generalist species capable of growing on a variety of carbon substrates. Further, C. difficile strains clustered by phylogenetic relationship and displayed ribotype-specific and clade-specific metabolic capabilities. Sur

SUBMITTER: Midani FS 

PROVIDER: S-EPMC11343193 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature