Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice.

ABSTRACT: Laboratory mice (Mus musculus domesticus) harbor gut bacterial strains that are distinct from those of wild mice¹ but whose evolutionary histories are poorly understood. Understanding the divergence of laboratory-mouse gut microbiota (LGM) from wild-mouse gut microbiota (WGM) is critical, because LGM and WGM have been previously shown to differentially affect mouse immune-cell proliferation^2,3, infection resistance⁴, cancer progression², and ability to model drug outcomes for humans⁵. Here, we show that laboratory mice have retained gut bacterial symbiont lineages that diversified in parallel (co-diversified) with rodent species for > 25 million years, but that LGM strains of these ancestral symbionts have experienced accelerate

SUBMITTER: Sprockett DD 

PROVIDER: S-EPMC11343198 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature