Exposures and conditions prior to age 16 are associated with dementia status among adults in the United States Health and Retirement Study.

ABSTRACT:

Background

Dementia susceptibility likely begins years before symptoms. Early life has not been comprehensively tested for dementia associations.

Method

In the US Health and Retirement Study (normal baseline cognition; n=16,509; 2008-2018 waves), 31 exposures before age 16 were retrospectively assessed with ten-year incident cognitive status (dementia, impaired, normal). Using parallel logistic models, each exposure was tested with incident cognition, adjusting for sex, baseline age, follow-up, race/ethnicity, personal/parental education.

Result

14.5% had incident impairment and 5.3% had dementia. Depression was associated with 1.71 (95%CI:1.28,2.26) times higher odds of incident impairment, relative to normal cognition. Headaches/migraines were associated with 1.63 (

SUBMITTER: Cockell S 

PROVIDER: S-EPMC11343252 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature