Gene expression and alternative splicing analysis in a large-scale Multiple Sclerosis study.

ABSTRACT:

Background

Multiple Sclerosis (MS) is an autoimmune neurodegenerative disease affecting approximately 3 million people globally. Despite rigorous research on MS, aspects of its development and progression remain unclear. Understanding molecular mechanisms underlying MS is crucial to providing insights into disease pathways, identifying potential biomarkers for early diagnosis, and revealing novel therapeutic targets for improved patient outcomes.

Methods

We utilized publicly available RNA-seq data (GSE138614) from post-mortem white matter tissues of five donors without any neurological disorder and ten MS patient donors. This data was interrogated for differential gene expression, alternative splicing and single nucleotide variants as well as for functional enrichments in th

SUBMITTER: Sak M 

PROVIDER: S-EPMC11343266 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature