Outcomes for children with recurrent/refractory atypical teratoid rhabdoid tumor: A single-institution study with molecular correlation.

ABSTRACT:

Background

Survival data for recurrent pediatric atypical teratoid rhabdoid tumor (ATRT) and its association to molecular groups are extremely limited.

Methods

Single-institution retrospective study of 64 children less than 21 years old with recurrent or treatment-refractory (progressive disease [PD]) ATRT treated at St. Jude Hospital from January 2000 to December 2020. Demographic, clinicopathologic, treatment, molecular grouping (SHH, TYR, and MYC) and germline data were collected. Progression-free survival (PFS2: time from PD to subsequent first progression) and overall survival (OSpostPD: time from PD to death/last follow-up) were estimated by Kaplan-Meier analysis.

Results

Median age at and time from initial diagnosis to PD were 2.1 years (range: 0.5-17.9 years)

SUBMITTER: Carey SS 

PROVIDER: S-EPMC11343675 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature