Age-specific sex-differences in cerebral blood flow velocity in relation to haemoglobin levels.

ABSTRACT:

Introduction

Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors. We aimed to determine the age-specific interrelations between sex, Hb, and CBF velocity in a l

SUBMITTER: Mazzucco S 

PROVIDER: S-EPMC11343687 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature