Sleep spindles are reduced in children with Down syndrome and sleep-disordered breathing.

ABSTRACT:

Background

Children with Down syndrome (DS) are at increased risk of sleep-disordered breathing (SDB). We investigated sleep spindle activity, as a marker of sleep quality, and its relationship with daytime functioning in children with DS compared to typically developing (TD) children.

Methods

Children with DS and SDB (n = 44) and TD children matched for age, sex and SDB severity underwent overnight polysomnography. Fast or Slow sleep spindles were identified manually during N2/N3 sleep. Spindle activity was characterized as spindle number, density (number of spindles/h) and intensity (density × average duration) on central (C) and frontal (F) electrodes. Parents completed the Child Behavior Check List and OSA-18 questionnaires.

Results

In children with DS, spindle ac

SUBMITTER: Shetty M 

PROVIDER: S-EPMC11343711 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature