Dataset Information

Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality.

ABSTRACT:

Aims/hypothesis

Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes.

Methods

Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients were followed for the first occurrence of a composite CVD endpoint (myocardial infarction, coronary revascularisation, peripheral arterial disease, stroke, unstable angina, heart failure or CVD death), a three-component endpoint comprising major adverse cardiovascular events (MACE), and all-cause mortality. Ten-year risks were estimated using the Aalen-Johansen estimator considering non-CVD death as a competing risk. HRs were determined by Cox regression. Models were controlled for sex, age, calendar year at birth, family history of diabetes and born-at-term status.

Results

A total of 1187 composite CVD endpoints, 931 MACE, and 1094 deaths occurred during a median follow-up period of 8.5 years. The 10-year standardised composite CVD risk was 19.8% in participants with a birthweight <3000 g compared with 16.9% in participants with a birthweight of 3000-3700 g, yielding a risk difference (RD) of 2.9% (95% CI 0.4, 5.4) and an adjusted HR of 1.20 (95% CI 1.03, 1.40). The 10-year MACE risk for birthweight <3000 g was similarly elevated (RD 2.4%; 95% CI 0.1, 4.7; HR 1.22; 95% CI 1.01, 1.46). The elevated CVD risk was primarily driven by stroke, peripheral arterial disease and CVD death. All-cause mortality showed no substantial difference.

Conclusions/interpretation

Having a birthweight <3000 g is associated with higher CVD risk among patients with type 2 diabetes, driven primarily by risk of stroke and CVD death.

SUBMITTER: Hansen AL

PROVIDER: S-EPMC11343788 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature

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Publications

Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality.

Hansen Aleksander L AL Brøns Charlotte C Engelhard Leonie M LM Andersen Mette K MK Hansen Torben T Nielsen Jens S JS Vestergaard Peter P Højlund Kurt K Jessen Niels N Olsen Michael H MH Sørensen Henrik T HT Thomsen Reimar W RW Vaag Allan A

Diabetologia 20240522 8

<h4>Aims/hypothesis</h4>Low birthweight is a risk factor for type 2 diabetes and CVD. This prospective cohort study investigated whether lower birthweight increases CVD risk after diagnosis of type 2 diabetes.<h4>Methods</h4>Original midwife records were evaluated for 8417 participants recently diagnosed with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Patients were followed for the first occurrence of a composite CVD endpoint (myocardial infarcti ...[more]

PMID: 38777869

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Dataset Information

Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality.

Aims/hypothesis

Methods

Results

Conclusions/interpretation

Publications

Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality.

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