Altered domain-specific striatal functional connectivity in patients with Parkinson's disease and urinary symptoms.

ABSTRACT:

Background

In this study, we aimed at investigating the possible association of urinary symptoms with whole-brain MRI resting-state functional connectivity (FC) alterations from distinct striatal subregions in a large cohort of early PD patients.

Methods

Seventy-nine drug-naive PD patients (45 PD-urinary⁺/34 PD-urinary^-) and 38 healthy controls (HCs) were consecutively enrolled. Presence/absence of urinary symptoms were assessed by means of the Nonmotor Symptom Scale - domain 7. Using an a priori connectivity-based domain-specific parcellation, we defined three ROIs (per each hemisphere) for different striatal functional subregions (sensorimotor, limbic and cognitive) from which seed-based FC voxel-wise analyses were conducted over the whole brain.

R

SUBMITTER: Piramide N 

PROVIDER: S-EPMC11343795 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature