Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults.

ABSTRACT: Neurofilament light chain (NfL) is a neuron-specific structural protein released into the extracellular space, including body fluids, upon neuroaxonal damage. Despite evidence of a link in neurological disorders, few studies have examined the association of serum NfL with mortality in population-based studies. Data from the National Health and Nutrition Survey were utilized including 2,071 Non-Hispanic White, Non-Hispanic Black and Hispanic adult participants and adult participants of other ethnic groups (20-85 years) with serum NfL measurements who were followed for ≤ 6 years till 2019. We tested the association of serum NfL with mortality in the overall population and stratified by sex with the addition of potential interactive and mediating effects of cardio-metabolic risk factors and n

SUBMITTER: Beydoun MA 

PROVIDER: S-EPMC11343803 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature