Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties.

ABSTRACT:

Background and objectives

Saliva is a patient-friendly matrix for therapeutic drug monitoring (TDM) but is infrequently used in routine care. This is due to the uncertainty of saliva-based TDM results to inform dosing. This study aimed to retrieve data on saliva-plasma concentration and subsequently determine the physicochemical properties that influence the excretion of drugs into saliva to increase the foundational knowledge underpinning saliva-based TDM.

Methods

Medline, Web of Science and Embase (1974-2023) were searched for human clinical studies, which determined drug pharmacokinetics in both saliva and plasma. Studies with at least ten subjects and five paired saliva-plasma concentrations per subject were included. For each study, the ratio of the area under the conce

SUBMITTER: Nguyen TA 

PROVIDER: S-EPMC11343830 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature