Discordance between mean glucose and time in range in relation to HbA_1c in individuals with type 1 diabetes: results from the GOLD and SILVER trials.

ABSTRACT:

Aims/hypothesis

Previous studies have shown that individuals with similar mean glucose levels (MG) or percentage of time in range (TIR) may have different HbA_1c values. The aim of this study was to further elucidate how MG and TIR are associated with HbA_1c.

Methods

Data from the randomised clinical GOLD trial (n=144) and the follow-up SILVER trial (n=98) of adults with type 1 diabetes followed for 2.5 years were analysed. A total of 596 paired HbA_1c/continuous glucose monitoring measurements were included. Linear mixed-effects models were used to account for intra-individual correlations in repeated-measures data.

Results

In the GOLD trial, the mean age of the participants (± SD) was 44±13 years, 63 (44%) were female, and the mean HbA<

SUBMITTER: Sterner Isaksson S 

PROVIDER: S-EPMC11343832 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature