Bone metabolism in diabetes: a clinician's guide to understanding the bone-glucose interplay.

ABSTRACT: Skeletal fragility is an increasingly recognised, but poorly understood, complication of both type 1 and type 2 diabetes. Fracture risk varies according to skeletal site and diabetes-related characteristics. Post-fracture outcomes, including mortality risk, are worse in those with diabetes, placing these people at significant risk. Each fracture therefore represents a sentinel event that warrants targeted management. However, diabetes is a very heterogeneous condition with complex interactions between multiple co-existing, and highly correlated, factors that preclude a clear assessment of the independent clinical markers and pathophysiological drivers for diabetic osteopathy. Additionally, fracture risk calculators and routinely used clinical bone measurements generally underestimate fract

SUBMITTER: Sheu A 

PROVIDER: S-EPMC11343884 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature