Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study.

ABSTRACT:

Aims/hypothesis

While the association between coeliac disease and type 1 diabetes is well documented, the association of coeliac disease with type 2 diabetes risk remains undetermined. We conducted a nationwide cohort and Mendelian randomisation analysis to investigate this link.

Methods

This nationwide matched cohort used data from the Swedish ESPRESSO cohort including 46,150 individuals with coeliac disease and 219,763 matched individuals in the comparator group selected from the general population, followed up from 1969 to 2021. Data from 9053 individuals with coeliac disease who underwent a second biopsy were used to examine the association between persistent villous atrophy and type 2 diabetes. Multivariable Cox regression was employed to estimate the associations. In M

SUBMITTER: Yuan S 

PROVIDER: S-EPMC11343898 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature