Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study.

ABSTRACT: While previous observational studies have suggested a link between leukocyte counts and vascular dementia (VD), the causal relationship between leukocyte counts and various subtypes of VD remains elusive. This study aimed to investigate the causal relationship between five types of leukocyte counts and VD, with the goal of improving prevention and treatment strategies. In this study, leukocyte counts were used as the exposure variable, with genome-wide association study (GWAS) data sourced from both the UK Biobank and the Blood Cell Consortium. Additionally, GWAS data for five subtypes of vascular dementia were obtained from the FinnGen database. We conducted rigorous statistical analysis and visualization using Mendelian randomization (MR) to elucidate the potential causal relationship be

SUBMITTER: Liu S 

PROVIDER: S-EPMC11344047 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature