Metabolites profiling, in-vitro and molecular docking studies of five legume seeds for Alzheimer's disease.

ABSTRACT: Even though legumes are valuable medicinal plants with edible seeds that are extensively consumed worldwide, there is little information available on the metabolic variations between different dietary beans and their influence as potential anti-cholinesterase agents. High-resolution liquid chromatography coupled with mass spectrometry in positive and negative ionization modes combined with multivariate analysis were used to explore differences in the metabolic profiles of five commonly edible seeds, fava bean, black-eyed pea, kidney bean, red lentil, and chickpea. A total of 139 metabolites from various classes were identified including saponins, alkaloids, phenolic acids, iridoids, and terpenes. Chickpea showed the highest antioxidant and anti-cholinesterase effects, followed by kidney be

SUBMITTER: Ibrahim RM 

PROVIDER: S-EPMC11344142 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature