Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients.

ABSTRACT:

Background

Atopic dermatitis (AD) is a common disease, with particularly high prevalence found in Africa. It is increasingly recognized that patients with AD of different ethnic backgrounds have unique molecular signatures in the skin, potentially accounting for treatment response variations. Nevertheless, the skin profile of patients with AD from Africa is unknown, hindering development of new treatments targeted to this patient population.

Objective

To characterize the skin profile of patients with AD from Africa.

Methods

Gene expression studies, including RNA sequencing (using threshold of fold change of >2 and false discovery rate of <0.05) and real-time polymerase chain reaction, were performed on skin biopsies of Tanzanian patients with moderate-to-severe AD and

SUBMITTER: Lang CCV 

PROVIDER: S-EPMC11344219 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature