The EC90 of remifentanil for inhibiting endotracheal intubation responses under anesthesia induction with ciprofol: study protocol for a dose-finding trial with the biased-coin design.

ABSTRACT:

Background

Tracheal intubation may cause significant hemodynamic responses. Many drugs have been shown to be effective in modifying these cardiovascular responses, including remifentanil, fentanyl, sufentanil, and alfentanil. However, the 90% effect-site concentration (EC90) of remifentanil required to control cardiovascular responses to tracheal intubation when combined with ciprofol remains unclear. The purpose of this study was to determine the EC90 of remifentanil inhibiting cardiovascular responses to tracheal intubation during anesthesia induction with ciprofol using biased-coin design up-and-down sequential method (BC-UDM).

Methods

This is a prospective sequential allocation dose-finding study. American Society of Anesthesiologists physical status (ASA) I-II elective

SUBMITTER: Guo J 

PROVIDER: S-EPMC11344379 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature