Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium.
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ABSTRACT:
SUBMITTER: Loid M
PROVIDER: S-EPMC11344589 | biostudies-literature | 2024
REPOSITORIES: biostudies-literature
Publications
Aging promotes accumulation of senescent and multiciliated cells in human endometrial epithelium.
Loid Marina M Obukhova Darina D Kask Keiu K Apostolov Apostol A Meltsov Alvin A Tserpelis Demis D van den Wijngaard Arthur A Altmäe Signe S Yahubyan Galina G Baev Vesselin V Saare Merli M Peters Maire M Minajeva Ave A Adler Priit P Acharya Ganesh G Krjutškov Kaarel K Nikolova Maria M Vilella Felipe F Simon Carlos C Zamani Esteki Masoud M Salumets Andres A
Human reproduction open 20240812 3
<h4>Study question</h4>What changes occur in the endometrium during aging, and do they impact fertility?<h4>Summary answer</h4>Both the transcriptome and cellular composition of endometrial samples from women of advanced maternal age (AMA) are significantly different from that of samples from young women, suggesting specific changes in epithelial cells that may affect endometrial receptivity.<h4>What is known already</h4>Aging is associated with the accumulation of senescent cells in aging tissu ...[more]
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