In vitro model to simulate multiple drugs with distinct elimination half-lives.

ABSTRACT:

Objective

The prevalence of drug resistance in pathogens such as HIV and selected bacteria has been steadily rising, resulting in an increased need for using multiple agents concurrently. Agents used in these combination therapies may have different elimination half-lives in humans. There is an unmet need for in vitro models to evaluate the efficacy of these combinations to guide early drug development. In order to realistically reflect in vivo conditions, useful in vitro model systems must be capable of simulating multiple pharmacokinetic profiles with distinct elimination half-lives. The goal of this study was to experimentally simulate four pharmacokinetic profiles with distinct elimination half-lives in an in vitro hollow-fibre system.

Methods

For illustrative purposes,

SUBMITTER: Hudson CS 

PROVIDER: S-EPMC11344907 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature