Social and emotional alterations in mice lacking the short dystrophin-gene product, Dp71.

ABSTRACT:

Background

The Duchenne and Becker muscular dystrophies (DMD, BMD) are neuromuscular disorders commonly associated with diverse cognitive and behavioral comorbidities. Genotype-phenotype studies suggest that severity and risk of central defects in DMD patients increase with cumulative loss of different dystrophins produced in CNS from independent promoters of the DMD gene. Mutations affecting all dystrophins are nevertheless rare and therefore the clinical evidence on the contribution of the shortest Dp71 isoform to cognitive and behavioral dysfunctions is limited. In this study, we evaluated social, emotional and locomotor functions, and fear-related learning in the Dp71-null mouse model specifically lacking this short dystrophin.

Results

We demonstrate the presence of abno

SUBMITTER: Miranda R 

PROVIDER: S-EPMC11344925 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature