Transcriptomic analysis reveals distinct effects of cigarette smoke on murine airspace and bone-marrow derived macrophages.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is an inflammatory airway disease characterized by emphysema and chronic bronchitis and a leading cause of mortality worldwide. COPD is commonly associated with several comorbid diseases which contribute to exacerbated patient outcomes. Cigarette smoke (CS) is the most prominent risk factor for COPD development and progression and is known to be detrimental to numerous effector functions of lung resident immune cells, including phagocytosis and cytokine production. However, how CS mediates the various pathologies distant from the lung in COPD, and whether CS has a similar biological effect on systemic immune cells remains unknown.

Methods

C57BL/6 mice were exposed to 8 weeks of CS as an experimental model of COPD. Bone

SUBMITTER: Faherty L 

PROVIDER: S-EPMC11344945 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature