Identification of crosstalk genes and immune characteristics between Alzheimer's disease and atherosclerosis.

ABSTRACT:

Background

Advancements in modern medicine have extended human lifespan, but they have also led to an increase in age-related diseases such as Alzheimer's disease (AD) and atherosclerosis (AS). Growing research evidence indicates a close connection between these two conditions.

Methods

We downloaded four gene expression datasets related to AD and AS from the Gene Expression Omnibus (GEO) database (GSE33000, GSE100927, GSE44770, and GSE43292) and performed differential gene expression (DEGs) analysis using the R package "limma". Through Weighted gene correlation network analysis (WGCNA), we selected the gene modules most relevant to the diseases and intersected them with the DEGs to identify crosstalk genes (CGs) between AD and AS. Subsequently, we conducted functional enrich

SUBMITTER: An W 

PROVIDER: S-EPMC11345154 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature