Exploring the gut microbiota's effect on temporomandibular joint disorder: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Temporomandibular joint disorders (TMD) are highly prevalent among people. Numerous investigations have revealed the impact of gut microbiota in many diseases. However, the causal relationship between Temporomandibular joint disorders and gut microbiota remains unclear.

Methods

Genome-Wide Association Studies (GWAS) refer to the identification of sequence variations, namely single nucleotide polymorphisms (SNPs), existing across the entire human genome. GWAS data were collected on gut microbiota and TMD. Then, instrumental variables were screened through F-values and removal of linkage disequilibrium. These SNPs underwent mendelian analysis using five mathematical models. Sensitivity analysis was conducted to further verify the stability of the results. Pathogenic

SUBMITTER: Zhao K 

PROVIDER: S-EPMC11345233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature