Rapid prototyping of multi-compartment models for urea kinetics in hemodialysis: a System Dynamics approach.

ABSTRACT: Models of urea kinetics facilitate a mechanistic understanding of urea transfer and provide a tool for optimizing dialysis efficacy. Dual-compartment models have largely replaced single-compartment models as they are able to accommodate the urea rebound on the cessation of dialysis. Modeling the kinetics of urea and other molecular species is frequently regarded as a rarefied academic exercise with little relevance at the bedside. We demonstrate the utility of System Dynamics in creating multi-compartment models of urea kinetics by developing a dual-compartment model that is efficient, intuitive, and widely accessible to a range of practitioners. Notwithstanding its simplicity, we show that the System Dynamics model compares favorably with the performance of a more complex volume-average m

SUBMITTER: Rubin DM 

PROVIDER: S-EPMC11345323 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature