Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis.

ABSTRACT: Ovarian aging is a major factor for female subfertility. Multiple antioxidants have been applied in different clinical scenarios, but their effects on fertility in women with ovarian aging are still unclear. To address this, a meta-analysis was performed to evaluate the effectiveness and safety of antioxidants on fertility in women with ovarian aging. A total of 20 randomized clinical trials with 2617 participants were included. The results showed that use of antioxidants not only significantly increased the number of retrieved oocytes and high-quality embryo rates but also reduced the dose of gonadotropin, contributing to higher clinical pregnancy rates. According to the subgroup analysis of different dose settings, better effects were more pronounced with lower doses; in terms of antioxi

SUBMITTER: Shang Y 

PROVIDER: S-EPMC11345374 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature