¹⁸F-FDG-PET/MR imaging to monitor disease activity in large vessel vasculitis.

ABSTRACT: Disease-monitoring in large vessel vasculitis (LVV) is challenging. Simultaneous ¹⁸F-fluorodeoxyglucose positron emission tomography with magnetic resonance imaging (PET/MRI) provides functional assessment of vascular inflammation alongside high-definition structural imaging with a relatively low burden of radiation exposure. Here, we investigate the ability of PET/MRI to monitor LVV disease activity longitudinally in a prospective cohort of patients with active LVV. We demonstrate that both the PET and MRI components of the scan can distinguish active from inactive disease using established quantification methods. Using logistic-regression modelling of PET/MRI metrics, we devise a novel PET/MRI-specific Vasculitis Activity using MR PET (VAMP) score which is able to distinguish

SUBMITTER: Pugh D 

PROVIDER: S-EPMC11345444 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature