Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes.

ABSTRACT:

Background

Bariatric surgery is an effective treatment option for obesity and provides long-term weight loss and positive effects on metabolism, but the underlying mechanisms are poorly understood. Alterations in bile acid metabolism have been suggested as a potential contributing factor, but comprehensive studies in humans are lacking.

Methods

In this study, we analysed the postprandial responses of bile acids, C4 and FGF19 in plasma, and excretion of bile acids in faeces, before and after bariatric surgery in patients (n = 38; 74% females) with obesity with or without type 2 diabetes from the BARIA cohort.

Findings

We observed that total fasting plasma bile acid levels increased, and faecal excretion of bile acids decreased after surgery suggesting increased reabsor

SUBMITTER: Wahlstrom A 

PROVIDER: S-EPMC11345581 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature