Reconfigurable Optical Sensor for Metal-Ion-Mediated Label-Free Recognition of Different Biomolecular Targets.

ABSTRACT: Reconfiguration of chemical sensors, intended as the capacity of the sensor to adapt to novel operational scenarios, e.g., new target analytes, is potentially game changing and would enable rapid and cost-effective reaction to dynamic changes occurring at healthcare, environmental, and industrial levels. Yet, it is still a challenge, and rare examples of sensor reconfiguration have been reported to date. Here, we report on a reconfigurable label-free optical sensor leveraging the versatile immobilization of metal ions through a chelating agent on a nanostructured porous silica (PSiO₂) optical transducer for the detection of different biomolecules. First, we show the reversible grafting of different metal ions on the PSiO₂ surface, namely, Ni²⁺, Cu²⁺

SUBMITTER: Di Giulio T 

PROVIDER: S-EPMC11345716 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature