Interplay of physical and recognition performance using hierarchical continuous-time dynamic modeling and a dual-task training regime in Alzheimer's patients.

ABSTRACT: Training studies typically investigate the cumulative rather than the analytically challenging immediate effect of exercise on cognitive outcomes. We investigated the dynamic interplay between single-session exercise intensity and time-locked recognition speed-accuracy scores in older adults with Alzheimer's dementia (N = 17) undergoing a 24-week dual-task regime. We specified a state-of-the-art hierarchical Bayesian continuous-time dynamic model with fully connected state variables to analyze the bi-directional effects between physical and recognition scores over time. Higher physical performance was dynamically linked to improved recognition (-1.335, SD = 0.201, 95% Bayesian credible interval [BCI] [-1.725, -0.954]). The effect was short-term, lasting up to 5 days (-0.368, SD = 0.

SUBMITTER: Schwarck S 

PROVIDER: S-EPMC11345748 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature