(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers.

ABSTRACT: The radiohybrid (rh) concept to design targeted (and chemically identical) radiotracers for imaging or radionuclide therapy of tumors has gained momentum. For this strategy, a new bifunctional Silicon-based Fluoride Acceptor (SiFA) moiety (SiFA)SeFe was synthesized, endowed with improved hydrophilicity and high versatility of integration into rh-compounds. Preliminary radiolabeling and stability studies under different conditions were conducted using model bioconjugate peptides. Further, three somatostatin receptor 2 (sstR2)-targeted rh-compounds ((SiFA)SeFe-rhTATE1-3, TATE = (Tyr³)-octreotate) were developed. Compound (SiFA)SeFe-rhTATE3, enables labeling with ¹⁸F for PET imaging or chelation of ¹⁷⁷Lu for therapy. The rh-compounds posse

SUBMITTER: Deiser S 

PROVIDER: S-EPMC11345769 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature