Ontology highlight
ABSTRACT:
SUBMITTER: Abel L
PROVIDER: S-EPMC11345826 | biostudies-literature | 2024 Jul
REPOSITORIES: biostudies-literature
Abel Laurent L Casanova Jean-Laurent JL
Immunity 20240701 7
Regardless of microbial virulence (i.e., the global infection-fatality ratio), age generally drives the prevalence of death from infection in unvaccinated humans. Four mortality patterns are recognized: the common U- and L-shaped curves of endemic infections and the unique W- and J-shaped curves of pandemic infections. We suggest that these patterns result from different sets of human genetic and immunological determinants. In this model, it is the interplay between (1) monogenic genotypes affec ...[more]