Coffee pulp improves glucose and lipid metabolism disorder in high-fat diet-induced diabetic mice.

ABSTRACT:

Background

Coffee berry extracts are anti-lipogenic and lipolytic. This study aims to investigate the effect and mechanism of coffee pulp on high-fat diet (HFD)-induced glucose and lipid metabolism disorder in mice.

Methods

The type 2 diabetes (T2D) mouse model was established by feeding the C57BL/6 J mice with HFD. Mice were administered with coffee pulp diluted in drinking water before or after the establishment of the T2D mouse model. After treatment, the body weight and fasting blood glucose (FBG) of mice were monitored; the intraperitoneal glucose tolerance test (IPGTT) of mice was performed; plasma insulin was determined by ELISA; serum total cholesterol (TC), triglyceride (TG) and liver TG were determined by biochemical analysis; hematoxylin-eosin (H&E) staining was u

SUBMITTER: Zhu S 

PROVIDER: S-EPMC11345893 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature