Adaptive evolution of A-to-I auto-editing site in Adar of eusocial insects.

ABSTRACT:

Background

Adenosine-to-inosine (A-to-I) RNA editing is a co-/post-transcriptional modification introducing A-to-G variations in RNAs. There is extensive discussion on whether the flexibility of RNA editing exerts a proteomic diversification role, or it just acts like hardwired mutations to correct the genomic allele. Eusocial insects evolved the ability to generate phenotypically differentiated individuals with the same genome, indicating the involvement of epigenetic/transcriptomic regulation.

Methods

We obtained the genomes of 104 Hymenoptera insects and the transcriptomes of representative species. Comparative genomic analysis was performed to parse the evolutionary trajectory of a regulatory Ile > Met auto-recoding site in Adar gene.

Results

At genome level, the

SUBMITTER: Zheng C 

PROVIDER: S-EPMC11346018 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature