Mirtazapine decreased cocaine-induced c-fos expression and dopamine release in rats.

ABSTRACT:

Introduction

Chronic cocaine exposure induces an increase in dopamine release and an increase in the expression of the Fos protein in the rat striatum. It has been suggested that both are necessary for the expression of cocaine-induced alterations in behavior and neural circuitry. Mirtazapine dosing attenuated the cocaine-induced psychomotor and reinforcer effects.

Methods

The study evaluates the effect of chronic dosing of mirtazapine on cocaine-induced extracellular dopamine levels and Fos protein expression in rats. Male Wistar rats received cocaine (10 mg/Kg; i.p.) during the induction and expression of locomotor sensitization. The mirtazapine (30 mg/Kg; MIR), was administered 30 minutes before cocaine during the cocaine withdrawal. After each treatment, the locomotor ac

SUBMITTER: Barbosa-Mendez S 

PROVIDER: S-EPMC11346032 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature