Salivary gland organoid transplantation as a therapeutic option for radiation-induced xerostomia.

ABSTRACT:

Background

Xerostomia is a pathological condition characterized by decreased salivation due to salivary gland dysfunction and is frequently attributed to irreversible damage as a side effect of radiation therapy. Stem cell-derived organoid therapy has garnered attention as a promising avenue for resolving this issue. However, Matrigel, a hydrogel commonly used in organoid culture, is considered inappropriate for clinical use due to its undefined composition and immunogenicity. In this study, we aimed to develop a method for culturing collagen-based human salivary gland organoids (hSGOs) suitable for clinical applications and evaluated their therapeutic effectiveness.

Methods

Human salivary gland stem cells were isolated from the salivary gland tissues and cultured in both Ma

SUBMITTER: Jeon SG 

PROVIDER: S-EPMC11346288 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature