Characteristics and function of the gut microbiota in patients with IgA nephropathy via metagenomic sequencing technology.

ABSTRACT:

Objective

The aim of this study was to investigate the characteristics and related functional pathways of the gut microbiota in patients with IgA nephropathy (IgAN) through metagenomic sequencing technology.

Methods

We enrolled individuals with primary IgAN, including patients with normal and abnormal renal function. Additionally, we recruited healthy volunteers as the healthy control group. Stool samples were collected, and species and functional annotation were performed through fecal metagenome sequencing. We employed linear discriminant analysis effect size (LEfSe) analysis to identify significantly different bacterial microbiota and functional pathways. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis was used to annotate microbiota functions, and redundancy anal

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11346320 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature