The plasma proteome is linked with left ventricular and left atrial function parameters in patients with chronic heart failure.

ABSTRACT:

Aims

Examining the systemic biological processes in the heterogeneous syndrome of heart failure with reduced ejection fraction (HFrEF), as reflected by circulating proteins, in relation to echocardiographic characteristics, may provide insights into heart failure pathophysiology. We investigated the link of 4210 repeatedly measured circulating proteins with repeatedly measured echocardiographic parameters as well as with elevated left atrial pressure (LAP), in patients with HFrEF, to provide insights into underlying mechanisms.

Methods and results

In 173 patients with HFrEF, we performed 6-monthly echocardiography and trimonthly blood sampling during a median follow-up of 2.7 (inter-quartile range: 2.5-2.8) years. We investigated circulating proteins in relation to echocardi

SUBMITTER: Abou Kamar S 

PROVIDER: S-EPMC11346355 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature