SegVir: Reconstruction of Complete Segmented RNA Viral Genomes from Metatranscriptomes.

ABSTRACT: Segmented RNA viruses are a complex group of RNA viruses with multisegment genomes. Reconstructing complete segmented viruses is crucial for advancing our understanding of viral diversity, evolution, and public health impact. Using metatranscriptomic data to identify known and novel segmented viruses has sped up the survey of segmented viruses in various ecosystems. However, the high genetic diversity and the difficulty in binning complete segmented genomes present significant challenges in segmented virus reconstruction. Current virus detection tools are primarily used to identify nonsegmented viral genomes. This study presents SegVir, a novel tool designed to identify segmented RNA viruses and reconstruct their complete genomes from complex metatranscriptomes. SegVir leverages both close

SUBMITTER: Tang X 

PROVIDER: S-EPMC11346362 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature