Gut microbiota mediates anxiety-like behaviors induced by chronic infection of Toxoplasma gondii in mice.

ABSTRACT:

Background

Chronic infection with the neurotropic parasite Toxoplasma gondii (T. gondii) can cause anxiety and gut microbiota dysbiosis in hosts. However, the potential role of gut microbiota in anxiety induced by the parasite remains unclear.

Methods

C57BL/6J mice were infected with 10 cysts of T. gondii. Antibiotic depletion of gut microbiota and fecal microbiota transplantation experiments were utilized to investigate the causal relationship between gut microbiota and anxiety. Anxiety-like behaviors were examined by the elevated plus maze test and the open field test; blood, feces, colon and amygdala were collected to evaluate the profiles of serum endotoxin (Lipopolysaccharide, LPS) and serotonin (5-hydroxytryptamine, 5-HT), gut microbiota composition, meta

SUBMITTER: Luo X 

PROVIDER: S-EPMC11346544 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature