Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals.

ABSTRACT:

Background

The expression of gene batteries, genomic units of functionally linked genes which are activated by similar sets of cis- and trans-acting regulators, has been proposed as a major determinant of cell specialization in metazoans. We developed a predictive procedure to screen the mouse and human genomes and transcriptomes for cases of gene-battery-like regulation.

Results

In a screen that covered approximately 40 percent of all annotated protein-coding genes, we identified 21 co-expressed gene clusters with statistically supported sharing of cis-regulatory sequence elements. 66 predicted cases of over-represented transcription factor binding motifs were validated against the literature and fell into three categories: (i) previously described cases of gene battery-lik

SUBMITTER: Nelander S 

PROVIDER: S-EPMC1134656 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature