Parallel organization of contralateral and ipsilateral prefrontal cortical projections in the rhesus monkey.

ABSTRACT:

Background

The neocortical commissures have a fundamental role in functional integration across the cerebral hemispheres. We investigated whether commissural projections in prefrontal cortices are organized according to the same or different rules as those within the same hemisphere, by quantitatively comparing density, topography, and laminar origin of contralateral and ipsilateral projections, labeled after unilateral injection of retrograde tracers in prefrontal areas.

Results

Commissural projection neurons constituted less than one third of the ipsilateral. Nevertheless, projections from the two hemispheres were strongly correlated in topography and relative density. We investigated to what extent the distribution of contralateral projections depended on: (a) geographic

SUBMITTER: Barbas H 

PROVIDER: S-EPMC1134662 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature