Impact of Hypertension on the Dose-Response Association Between Physical Activity and Stroke: A Cohort Study.

ABSTRACT:

Background

Regular physical activity is associated with a reduced stroke risk. However, this relationship might be attenuated in the presence of hypertension and antihypertensive medication use. We examined the dose-response relationship between physical activity and stroke in normotensive and hypertensive individuals.

Methods

A Dutch population-based cohort including 139 930 individuals (41% men; mean age, 44±13) was performed (median follow-up, 6.75 years). Participants were stratified at baseline as hypertensive (44%) or normotensive (56%) and categorized into quartiles of the lowest (Q1) to the highest (Q4) moderate-to-vigorous, self-reported physical activity. The primary outcome was incident stroke (fatal and nonfatal). Cox regression estimated hazard ratios and 95% CI

SUBMITTER: McLellan HL 

PROVIDER: S-EPMC11346707 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature