Pan-cancer analysis of immune checkpoint receptors and ligands in various cells in the tumor immune microenvironment.

ABSTRACT: Drugs that target immune checkpoint have become the most popular weapon in cancer immunotherapy, yet only have practical benefits for a small percentage of patients. Tumor cells constantly interact with their microenvironment, which is made up of a variety of immune cells as well as endothelial cells and fibroblasts. Immune checkpoint expression and blocked signaling of immune cells in the tumor microenvironment (TME) are key to tumor progression. In this study, we perform deliberation convolution on the TCGA database for human lung, breast, and colorectal cancer to infer crosstalk between immune checkpoint receptors (ICRs) and ligands (ICLs) in TME of pan-carcinogenic solid tumor types, validated by flow cytometry. Analysis of immune checkpoints showed that there was little variation betw

SUBMITTER: Jiang J 

PROVIDER: S-EPMC11346784 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature