The deubiquitinating enzymes-related signature predicts the prognosis and immunotherapy response in breast cancer.

ABSTRACT:

Background

Breast cancer is a prevalent disease that has a dismal prognosis for patients and a bad outlook for treatments. Ubiquitination is a reversible biological process that regulates protein production and degradation, as well as plays a vital role in protein transport, localization, and biological activity.

Methods

We obtained the breast cancer patient sample data and used a machine learning technique to create a novel index called Deubiquitinating enzyme related index (DUBRI) by gathering genes associated to deubiquitinating enzymes. Based on DUBRI, we systematically analyze patients' prognosis, clinical characteristics, tumor immune microenvironment, chemotherapy response and immunotherapy response. Finally, the function of OTUB2 was explored in breast cancer cells.<

SUBMITTER: Deng Y 

PROVIDER: S-EPMC11346791 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature