Potential impact of curative and preventive interventions toward hepatitis C elimination in people who inject drugs-A network modeling study.

ABSTRACT:

Background

Injection-equipment-sharing networks play an important role in hepatitis C virus (HCV) transmission among people who inject drugs (PWID). Direct-acting antiviral (DAA) treatments for HCV infection and interventions to prevent HCV transmission are critical components of an overall hepatitis C elimination strategy, but how they contribute to the elimination outcomes in different PWID network settings are unclear.

Methods

We developed an agent-based network model of HCV transmission through the sharing of injection equipment among PWID and parameterized and calibrated the model with rural PWID data in the United States. We modeled curative and preventive interventions at annual coverage levels of 12.5 %, 25 %, or 37.5 % (cumulative percentage of eligible individuals

SUBMITTER: Zhu L 

PROVIDER: S-EPMC11347083 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature