Metabolite profile in hereditary spastic paraplegia analyzed using magnetic resonance spectroscopy: a cross-sectional analysis in a longitudinal study.

ABSTRACT:

Background

Hereditary Spastic Paraplegias (HSP) are genetic neurodegenerative disorders affecting the corticospinal tract. No established neuroimaging biomarker is associated with this condition.

Methods

A total of 46 patients affected by HSP, genetically and clinically evaluated and tested with SPRS scores, and 46 healthy controls (HC) matched by age and gender underwent a single-voxel Magnetic Resonance Spectroscopy sampling (MRS) of bilateral pre-central and pre-frontal regions. MRS data were analyzed cross-sectionally (at T₀ and T₁) and longitudinally (T₀ vs. T₁).

Results

Statistically significant data showed that T₀ mI/Cr in the pre-central areas of HSP patients was higher than in HC. In the left (L) pre-cent

SUBMITTER: Montanaro D 

PROVIDER: S-EPMC11347332 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature