Single versus multiple fraction stereotactic radiosurgery for medium-sized brain metastases (4-14 cc in volume): reducing or fractionating the radiosurgery dose?

ABSTRACT:

Background and purpose

Stereotactic radiosurgery (SRS) of brain metastases (BM) and resection cavities is a widely used and effective treatment modality. Based on target lesion size and anatomical location, single fraction SRS (SF-SRS) or multiple fraction SRS (MF-SRS) are applied. Current clinical recommendations conditionally recommend either reduced dose SF-SRS or MF-SRS for medium-sized BM (2-2.9 cm in diameter). Despite excellent local control rates, SRS carries the risk of radionecrosis (RN). The purpose of this study was to assess the 12-months local control (LC) rate and 12-months RN rate of this specific patient population.

Materials and methods

This single-center retrospective study included 54 patients with medium-sized intact BM (n=28) or resection cavities (n=30

SUBMITTER: Reinhardt P 

PROVIDER: S-EPMC11347337 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature