Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response.

ABSTRACT:

Introduction

Influenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunopathology, but predicting which individuals are at a higher risk of being hospitalized warrants investigation into host genetics and the molecular signatures of the host response during influenza infections.

Methods

Here, we performed transcriptome and genotype analysis in healthy controls and patients exhibiting mild/moderate or severe influenza (ICU patients). A unique aspect of our study was the genotyping of all participants, which allowed us to assign ethnicities based on genetic variation and assess whether the variation wa

SUBMITTER: Schughart K 

PROVIDER: S-EPMC11347429 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature